Darci R. Block, Ph.D.

  1. Chemist
  1. Thompson C, Block D, Wang Z, Foster N, Hassett LC, Steien D, Galardy P, Al-Huniti A. The Global Prevalence of Iron Deficiency in Collegiate Athletes: A Systematic Review and Meta-Analysis. Pediatr Blood Cancer. 2024 Nov 12; e31415 [Epub ahead of print]
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  2. Thompson C, Trushina E, Fairweather D, Block D, Wang Z, Foster N, Steien D, Galardy P, Al-Huniti A. Iron Deficiency in Collegiate Athletes Obtaining Preparticipation Hemoglobinopathy Screening in the Upper Midwest. Pediatr Blood Cancer. 2024 Nov 11; e31437 [Epub ahead of print]
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  3. Block DR, Lasho MA, Donato LJ, Meeusen JW. Establishing hemolysis, icterus, and lipemia interference limits for body fluid chemistry analytes measured on the Roche cobas instrument. Am J Clin Pathol. 2024 Oct 3; 162 (4):356-368
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  4. Silber MH, Block DR, Louis EKS. Serum ferritin measurements differ according to assay used: implications for iron therapy in restless legs syndrome. J Clin Sleep Med. 2024 Aug 22 [Epub ahead of print]
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  5. Chandrasekar AP, Wang Q, Block DR. "It's Pink!". Clin Chem. 2024 Mar 2; 70 (3):565-566
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  6. Chandrasekar AP, Wang Q, Block DR. "It's Pink!". Clinical Chemistry. 2024; 70 (3):565-6
  7. Chandrasekar A, Wang Q, Block DR. What is Your Guess? "It's Pink!" Clinical Chemistry. 11/3/2023; in press.
  8. Galior KD, Ladwig PM, Snyder MR, Algeciras-Schimnich A, Bornhorst JA, Block DR, Baumann NA, Willrich MAV. Lack of observed interference by therapeutic monoclonal antibodies in select commonly utilized immunoassays. Clin Biochem. 2023 Nov; 121-122:110685 Epub 2023 Nov 14
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  9. Vanderboom P, Block DR. Autoverification in the Core Clinical Laboratory PathologyOutlines.com, Inc. 2023. Epub 2023 Oct 03.
  10. Cotten SW, Block DR. A Review of Current Practices and Future Trends in Body Fluid Testing. J Appl Lab Med. 2023 Sep 7; 8 (5):962-983
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  11. Block DR. Commentary on A Patient with Third-Space Fluid Loss. Clin Chem. 2023 Feb 1; 69 (2):128-129
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  12. Fautsch KJ, Block DR, Graff-Radford J, Wang F, Craver EC, Hodge DO, Cutsforth-Gregory JK, Kilgore KP, Petersen RC, Knopman DS, Flanagan E, Toledano M, Mielke MM, Bhatti MT, Chen JJ. Population-Based Evaluation of Total Protein in Cerebrospinal Fluid. Mayo Clin Proc. 2023 Feb; 98(2):239-251.
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  13. Wheeler SE, Block DR, Bunch DR, Gramz J, Leung EKY, McClintock DS, Tuthill JM. Clinical Laboratory Informatics and Analytics: Challenges and Opportunities. Clin Chem. 2022 Nov 3; 68 (11):1361-1367
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  14. Fatica EM, Jenkins SM, Scott RJ, Block DR, Meeusen JW, Baumann NA, Saenger AK, Donato LJ. Short- and Long-Term Biological Variability of Small Dense LDL, HDL3, and Triglyceride-Rich Lipoprotein Cholesterol. J Appl Lab Med. 2022 Sep 1; 7 (5):1047-1061
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  15. Block DR, Cotten SW, Franke D, Mbughuni MM. Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens. Am J Clin Pathol. 2022 Jul 1; 158 (1):47-61
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  16. Block DR, Cotten SW, Franke D, Mbughuni MM. Corrigendum to: Comparison of Five Common Analyzers in the Measurement of Chemistry Analytes in an Authentic Cohort of Body Fluid Specimens. Am J Clin Pathol. 2022 Jul 1; 158 (1):157
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  17. Ramos P, Jenkins SM, Donato LJ, Hartman SJ, Saenger A, Baumann NA, Block DR, Jaffe AS, Meeusen JW. The Biological Variability of Plasma Ceramides in Healthy Subjects. J Appl Lab Med. 2022 Jun 30; 7(4):863-870.
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  18. Nandakumar V, Dolan CT, Baumann NA, Block DR. Effect of pH on the Quantification of Common Chemistry Analytes in Body Fluid Specimens Using the Roche cobas Analyzer for Clinical Diagnostic Testing. Am J Clin Pathol. 2021 Oct 13; 156 (5):722-727
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  19. Sankaranarayanan S, Balan J, Walsh JR, Wu Y, Minnich S, Piazza A, Osborne C, Oliver GR, Lesko J, Bates KL, Khezeli K, Block DR, DiGuardo M, Kreuter J, O'Horo JC, Kalantari J, Klee EW, Salama ME, Kipp B, Morice WG, Jenkinson G. COVID-19 Mortality Prediction From Deep Learning in a Large Multistate Electronic Health Record and Laboratory Information System Data Set: Algorithm Development and Validation. J Med Internet Res. 2021 Sep 28; 23(9):e30157.
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  20. Ivy MI, Sharma K, Greenwood-Quaintance KE, Tande AJ, Osmon DR, Berbari EF, Mandrekar J, Beauchamp CP, Hanssen AD, Abdel MP, Lewallen DG, Perry K, Block DR, Snyder MR, Patel R. Synovial fluid alpha defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection diagnosis. Bone Joint J. 2021 Jun; 103-B (6):1119-1126
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  21. Sharma K, Ivy M, Block DR, Abdel MP, Hanssen AD, Beauchamp C, Perry KI, Rosemark CL, Greenwood-Quaintance KE, Mandrekar J, Patel R. Comparative analysis of 23 synovial fluid biomarkers for hip and knee periprosthetic joint infection detection. J Orthop Res. 2020 Dec; 38 (12):2664-2674 Epub 2020 June 19
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  22. Madigan T, Block DR, Carey WA, Kaemingk BD, Patel R. Proposed Plasma Ammonia Reference Intervals in a Reference Group of Hospitalized Term and Preterm Neonates. J Appl Lab Med. 2020 Mar 1; 5 (2):363-369
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  23. Katrangi W, Baumann NA, Nett RC, Karon BS, Block DR. Prevalence of Clinically Significant Differences in Sodium Measurements Due to Abnormal Protein Concentrations Using an Indirect Ion-Selective Electrode Method. J Appl Lab Med. 2019 Nov; 4 (3):427-432 Epub 2019 Aug 23
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  24. Block DR, Griesmann LD, Rickard T, Backus L, Finley J, Goyal D, Karon BS. Continuous Improvement of Blood Redraw Rates in the Emergency Department: A 5-Year Journey Journal of Applied Laboratory Medicine. 2019; 4(2):284-286. Epub 2019 Aug 02.
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  25. Jara-Aguirre JC, Baumann NA, Block DR, Algeciras-Schimnich A. Human chorionic gonadotropin suspected heterophile interference investigations in immunoassays: a recommended approach. Clin Chem Lab Med. 2019 Jul 26; 57 (8):1192-1196
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  26. Juskewitch JE, Norgan AP, Johnson RD, Trivedi VA, Hanson CA, Block DR. Impact of an electronic decision support rule on ESR/CRP co-ordering rates in a community health system and projected impact in the tertiary care setting and a commercially insured population. Clin Biochem. 2019 Apr; 66:13-20 Epub 2019 Jan 31
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  27. Block DR, Ouverson LJ, Wittwer CA, Saenger AK, Baumann NA. An approach to analytical validation and testing of body fluid assays for the automated clinical laboratory. Clin Biochem. 2018 Aug; 58:44-52 Epub 2018 May 05
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  28. Shah KK, Mbughuni MM, Burgstaler EA, Block DR, Winters JL. Iatrogenic thyrotoxicosis and the role of therapeutic plasma exchange. J Clin Apher. 2017 Dec; 32 (6):579-583 Epub 2017 Mar 20
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  29. Karon BS, Tolan NV, Wockenfus AM, Block DR, Baumann NA, Bryant SC, Clements CM. Evaluation of lactate, white blood cell count, neutrophil count, procalcitonin and immature granulocyte count as biomarkers for sepsis in emergency department patients. Clin Biochem. 2017 Nov; 50 (16-17):956-958 Epub 2017 May 25
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  30. Parakh R, Greene DN, Mathias PC, Block DR, Ranjitkar P. Laboratory Utilization and Analytical Validation of Fecal Electrolyte Tests. J Appl Lab Med. 2017 May 1; 1 (6):668-677
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  31. Donato LJ, Meeusen JW, Jenkins SM, Hartman SJ, Saenger AK, Baumann NA, Block DR, Jaffe AS. Biological variability of lipoprotein-associated phospholipase A2 activity in healthy individuals. Clin Biochem. 2017 Apr; 50 (6):347-349 Epub 2016 Nov 25
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  32. Wang X, Greenwood-Quaintance KE, Karau MJ, Block DR, Mandrekar JN, Cunningham SA, Mallea JM, Patel R. Ureaplasma parvum causes hyperammonemia in a pharmacologically immunocompromised murine model. Eur J Clin Microbiol Infect Dis. 2017 Mar; 36 (3):517-522 Epub 2016 Oct 28
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  33. Block DR, Rickard TM, Johnson SR, Griesmann LD, Kang NS. Pediatric Phlebotomy Services: Optimizing Sample Quality and Improving the Patient and Parent Experience. J Appl Lab Med. 2017 Jan 1; 1 (4):453-456
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  34. Moyer AM, Saenger AK, Willrich M, Donato LJ, Baumann NA, Block DR, Botz CM, Khan MA, Jaffe AS, Hanson CA, Karon BS. Implementation of Clinical Decision Support Rules to Reduce Repeat Measurement of Serum Ionized Calcium, Serum Magnesium, and N-Terminal Pro-B-Type Natriuretic Peptide in Intensive Care Unit Inpatients. Clin Chem. 2016 Jun; 62 (6):824-30 Epub 2016 Mar 28
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  35. Akbas N, Draganova EB, Block DR, Sook BR, Chan YF, Zhuo J, Eichenbaum Z, Rodgers KR, Dixon DW. Heme-bound SiaA from Streptococcus pyogenes: Effects of mutations and oxidation state on protein stability. J Inorg Biochem. 2016 May; 158:99-109.
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  36. Bauer PR, Kashyap R, League SC, Park JG, Block DR, Baumann NA, Algeciras-Schimnich A, Jenkins SM, Smith CY, Gajic O, Abraham RS. Diagnostic accuracy and clinical relevance of an inflammatory biomarker panel for sepsis in adult critically ill patients. Diagn Microbiol Infect Dis. 2016 Feb; 84 (2):175-80 Epub 2015 Oct 09
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  37. Wang X, Karau MJ, Greenwood-Quaintance KE, Block DR, Mandrekar JN, Cunningham SA, Patel R. Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model. PLoS One. 2016; 11 (8):e0161214 Epub 2016 Aug 18
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  38. Voskoboev NV, Cambern SJ, Hanley MM, Giesen CD, Schilling JJ, Jannetto PJ, Lieske JC, Block DR. Fecal electrolyte testing for evaluation of unexplained diarrhea: Validation of body fluid test accuracy in the absence of a reference method. Clin Biochem. 2015 Nov; 48: (16-17)1126-30.
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  39. Willrich MA, Wittwer CA, Baumann NA, Block DR. A dark-brown serum sample. Clin Chem. 2015 Jul; 61(7):999-1000.
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  40. Akbas N, Schryver PG, Algeciras-Schimnich A, Baumann NA, Block DR, Budd JR, Gaston SJ, Klee GG. Evaluation of Beckman Coulter DxI 800 immunoassay system using clinically oriented performance goals. Clin Biochem. 2014 Nov; 47(16-17):158-63. Epub 2014 Aug 15.
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  41. Tange JI, Grill D, Koch CD, Ybabez RJ, Krekelberg BJ, Fylling KA, Wiese CR, Baumann NA, Block DR, Karon BS, Chen D, Pruthi RK. Local verification and assignment of mean normal prothrombin time and International Sensitivity Index values across various instruments: recent experience and outcome from North America. Semin Thromb Hemost. 2014 Feb; 40(1):115-20. Epub 2013 Dec 31.
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  42. Block DR, Wockenfus AM, Koch CD, Karon BS. Analytical performance of three point of care methods for pleural fluid pH analysis. Clin Biochem. 2013 Aug; 46 (12):1139-1141 Epub 2013 Apr 30
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  43. Block DR, Algeciras-Schimnich A. Body fluid analysis: clinical utility and applicability of published studies to guide interpretation of today's laboratory testing in serous fluids. Crit Rev Clin Lab Sci. 2013 Jul-Oct; 50(4-5):107-24.
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  44. Kaleta EJ, Jaffe AS, Baumann NA, Block DR. A case of floating gel. Clin Chem. 2012 Nov; 58 (11):1604-5
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  45. Block DR, Lieske JC. Automated urinalysis in the clinical lab. MLO Med Lab Obs. 2012 Oct; 44(10):8-10, 12; quiz 14.
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  46. Block DR, Jenkins SM, Dalenberg DA, Balsanek JG, Snyder MR, Saenger AK. Analytical and clinical comparison of anti-CCP assays with rheumatoid factor for the diagnosis of rheumatoid arthritis. Clin Chim Acta. 2012 Jun 14; 413 (11-12):1015-7 Epub 2012 Feb 14
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  47. Block DR, Saenger AK. What is your guess? The case of the milky white urine. Clin Chem. 2011 May; 57 (5):783-4
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  48. Block DR, Karon BS. Tips from Clinical Experts: Anticoagulant Testing. Medical Laboratory Observer. 03/2011; 43(3):37.
  49. Block DR, Saenger AK. Preeclampsia: Prediction, Diagnosis, and Management Beyond Proteinuria and Hypertension. Clinical Laboratory News, Series Article. 2010 Feb.
  50. Sook BR, Block DR, Sumithran S, Montanez GE, Rodgers KR, Dawson JH, Eichenbaum Z, Dixon DW. Characterization of SiaA, a streptococcal heme-binding protein associated with a heme ABC transport system. Biochemistry. 2008 Feb 26; 47(8):2678-88. Epub 2008 Feb 2
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  51. Block DR, Lukat-Rodgers GS, Rodgers KR, Wilks A, Bhakta MN, Lansky IB. Identification of two heme-binding sites in the cytoplasmic heme-trafficking protein PhuS from Pseudomonas aeruginosa and their relevance to function. Biochemistry. 2007 Dec 18; 46(50):14391-402. Epub 2007 Nov 20
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  52. Lansky IB, Lukat-Rodgers GS, Block D, Rodgers KR, Ratliff M, Wilks A. The cytoplasmic heme-binding protein (PhuS) from the heme uptake system of Pseudomonas aeruginosa is an intracellular heme-trafficking protein to the delta-regioselective heme oxygenase. J Biol Chem. 2006 May 12; 281(19):13652-62. Epub 2006 Mar 13
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