Print Overview Bullous pemphigoid Enlarge image Close Bullous pemphigoid Bullous pemphigoid People with bullous pemphigoid may develop multiple blisters. When the blisters rupture, they leave a sore that typically heals without scarring. Bullous pemphigoid (BUL-us PEM-fih-goid) is a rare skin condition that causes large, fluid-filled blisters. They develop on areas of skin that often flex — such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is most common in older adults. Bullous pemphigoid occurs when your immune system attacks a thin layer of tissue below your outer layer of skin. The reason for this abnormal immune response is unknown, although it sometimes can be triggered by taking certain medications. Bullous pemphigoid often goes away on its own in a few months, but may take as many as five years to resolve. Treatment usually helps heal the blisters and ease any itching. It may include corticosteroid medications, such as prednisone, and other drugs that suppress the immune system. Bullous pemphigoid can be life-threatening, especially for older people who are already in poor health.Products & ServicesA Book: Mayo Clinic Family Health BookNewsletter: Mayo Clinic Health Letter — Digital EditionShow more products from Mayo Clinic SymptomsThe signs and symptoms of bullous pemphigoid may include: Itching skin, weeks or months before blisters form Large blisters that don't easily rupture when touched, often along creases or folds in the skin Skin around the blisters that is normal, reddish or darker than normal Eczema or a hive-like rash Small blisters or sores in the mouth or other mucous membranes (benign mucous membrane pemphigoid) When to see a doctorSee your doctor if you develop: Unexplained blistering Blisters on your eyes Signs of infection Request an appointment CausesThe blisters occur because of a malfunction in your immune system. Your body's immune system normally produces antibodies to fight bacteria, viruses or other potentially harmful foreign substances. For reasons that are not clear, the body may develop an antibody to a particular tissue in your body. In bullous pemphigoid, the immune system produces antibodies to the fibers that connect the outer layer of skin (epidermis) and the next layer of skin (dermis). These antibodies trigger inflammation that produces the blisters and itching of bullous pemphigoid. Contributing factorsBullous pemphigoid usually appears randomly with no clear factors contributing to the onset of disease. Some cases may be triggered by: Medications. Prescription drugs that may cause bullous pemphigoid include etanercept (Enbrel), sulfasalazine (Azulfidine), furosemide (Lasix) and penicillin. Light and radiation. Ultraviolet light therapy to treat certain skin conditions may trigger bullous pemphigoid, as can radiation therapy to treat cancer. Medical conditions. Disorders that may trigger bullous pemphigoid include psoriasis, lichen planus, diabetes, rheumatoid arthritis, ulcerative colitis and multiple sclerosis. Risk factorsBullous pemphigoid most commonly occurs in older adults, and the risk increases with age. By Mayo Clinic Staff Request an appointment Diagnosis & treatment Sept. 27, 2022 Print Show references AskMayoExpert. Pemphigoid disorders. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. Barbara Woodward Lips Patient Education Center. Bullous pemphigoid. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2001. Peraza DM. Bullous pemphigoid. Merck Manual Professional Version. https://www.merckmanuals.com/professional/dermatologic-disorders/bullous-diseases/bullous-pemphigoid. Accessed Oct. 4, 2018. Leiferman KM. Clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2018. Leiferman KM. Epidemiology and pathogenesis of bullous pemphigoid and mucous membrane pemphigoid. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2018. Murrell DF, et al. Management and prognosis of bullous pemphigoid. https://www.uptodate.com/contents/search. Accessed Oct. 4, 2018. Saag KG, et al. Major side effects of systemic glucocorticoids. https://www.uptodate.com/contents/search. Accessed Sept. 19, 2018. Related Bullous pemphigoid Associated Procedures Skin biopsy Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Bullous pemphigoidSymptoms&causesDiagnosis&treatmentDoctors&departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. 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